Gonadorelin – Factrel

Gonadorelin is a synthetic version of gonadotropin-releasing hormone (GnRH), the hormone that tells the pituitary gland to release LH and FSH. Those two hormones drive the testes to keep producing testosterone and sperm. Because of this, it is mainly used to keep the pituitary-testicular axis active rather than to raise testosterone directly.

As a guide only and not medical advice, users commonly run small subcutaneous doses of around 100 to 200 mcg two to three times a day, spaced a few hours apart, using an insulin syringe for accurate measurement. Frequent small doses are used because GnRH signalling works in short pulses, and courses are typically kept short, in the region of 4 to 8 weeks. Always base your own protocol on guidance from a qualified professional.

The most commonly reported effects are mild, including some soreness or swelling at the injection site, occasional headache, nausea, or a brief feeling of lightheadedness or flushing after a dose. These are usually short-lived. If any reaction feels severe or does not settle, stop use and speak to a healthcare provider.

Both are used to support testicular function, but they work differently. hCG mimics LH directly at the testes, while Gonadorelin works one step earlier by prompting the pituitary itself to release LH and FSH. Some users pair the two, and Gonadorelin alongside testosterone is a common approach for maintaining natural signalling during a cycle.

Checking baseline LH, FSH, and total testosterone before starting is a sensible step, with a repeat panel around 2 to 4 weeks in to see how the pituitary is responding. This gives a much clearer picture than guessing, and any bloodwork should be reviewed with a licensed healthcare provider.

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