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Growth hormone, also called somatotropin, a hormone of the anterior pituitary gland secretion is controlled by the hypothalamic neurohormones – somatostatin (inhibits) and Somatoliberin (releases). The degree of secretion in the body reaches its highest value during puberty, when more tissue growth, protein deposition, and breakdown of the subcutaneous adipose tissue. Later GH decreases, but remains present. Somatotropin present in the body is a sequence of 191 amino acids. This hormone has been isolated by researchers for therapeutic purposes, especially for treating hypopituitarism. It appears to be an effective treatment for dwarfism, when therapies begin in adolescence.
The standard dose is in the range of 4-12 IU per day, which must be administered daily, because of the action of GH in the body is very short. Peak plasma concentration achieved after 2-6h after injection. When the hormone is gradually removed from the body. Gh itself should be given over many months and the minimum cycle should last for 6 weeks. Shorter cycles are only makes sense if our goal is to burn fat.
Gh after prolonged use creates new muscle fibers In order to achieve the best possible results, it is required to combine HGH with other pharmacological agents. During treatment with somatropin body needs larger amounts of thyroid hormones, insulin and androgens (the use of HGH reduces the level of thyroid hormone and insulin). Joining products containing thyroid hormones will greatly increase the teratogenic effect of the cycle. The best solution is to buy Cytomel’u or Synthroid’u used in the medical version of the T-3 and T-4. As a rule, the players choose the more powerful Cytomel. Another measure is welcome insulin dosage as for the anabolic treatment. Exogenous insulin not only recruits natural hormone pancreas. Also increases the sensitivity of receptors for IGF-1 and reduced levels of IGF-binding proteins allowing free circulation of more IGF-1. Another important element of treatment with the use of HGH is the appropriate use of anabolic steroids – androgenic. A good solution turns out to be a powerful means androgennie, testosterone or trenbolone. Androgen will favor the anabolic effect of treatment, increasing the size of muscle cells (HGH increases their number). The steroid may also increase free IGF-1 by reducing protein binding him (in a similar way as HGH). The correct combination of the measures mentioned above (HGH, anabolics, insulin, T-3) will provide significant synergistic effect, resulting in very satisfactory results. It should, however, note that both insulin and T-3 are means very strong, carrying additional high risk. HGH is essential for many metabolic processes. Enhances glucose metabolism in the liver and blocks the action of insulin. As a result, it mobilizes the resources of fat that the body can use fatty acids as the main source of energy. It protects the muscle proteins from breakdown
Growth hormone produces effects in the body:
– Anabolic – to a large extent caused indirectly by IGF-1 (amino acid uptake, increased transcription and translation of mRNA, inhibition of proteolysis, increasing the amount of nuclei in muscle cells, increased volume and weight of muscle fibers); – Lipolytic – (independently of the IGF-1) by direct activation of adenylate cyclase, then the activation of cAMP-dependent protein kinase, and phosphorylation and activation of hormone-sensitive lipase; – Diabetogenic – (reduces carbohydrate utilization by hindering the uptake of glucose); – Stimulating long bone growth; – Stimulating the immune system (increased antibody production, T cell interleukin-2, leukocyte, activated NK cells, macrophages accelerates the maturation of the tissues increases T lymphocytes migrate to the thymus); – Modulating central nervous system condition in young people (cognitive function, sleep, mood); – Mitogenic – (stimulates erythropoiesis in vitro and in vivo, in vitro and in experimental animals to induce the development of cancer – lymphomas, leukemias, cancer of the bladder).
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