Aicar – AICA ribonucleotide

AICAR (AICA ribonucleotide) is a research compound that activates AMP-activated protein kinase, AMPK, the same pathway your muscles switch on during sustained endurance exercise. In lab studies this activation drives glucose uptake, fatty acid oxidation and mitochondrial biogenesis, which is why it is often described as an exercise mimetic. This vial from Syncom Labs is 50mg for research use, not for human consumption.

There is no established human dosing protocol for AICAR, so any figures floating around are extrapolated from animal studies rather than clinical use. Published research uses doses around 50mg per kg of body weight, injected intraperitoneally in the studies it comes from, which does not translate directly to a person. This is general research context, not a usage instruction, and it should not be used as a guide for dosing yourself.

The main concern flagged in the research literature is hypoglycaemia, since AICAR pushes glucose uptake independently of insulin, along with reported cardiac arrhythmia, nausea and headache. Blood glucose should be the top priority to track if this compound is being used in a research context, alongside cardiac markers such as troponin and an ECG. There is no on-cycle support protocol established for AICAR, so anyone working with it should treat glucose monitoring as essential rather than optional.

No. AICAR carries limited human data and real risk of severe hypoglycaemia and cardiac effects, so it is not a starting point compound. Someone newer to AMPK-pathway compounds is generally better served by looking at cardarine (GW501516), which targets a related metabolic pathway with a more established research profile.

Both AICAR and cardarine influence metabolic pathways tied to endurance and fat oxidation, and the two are sometimes discussed together in research on exercise mimetics. Cardarine works through PPAR-delta rather than AMPK directly and has a broader body of research behind it, whereas AICAR's human data is far thinner. Anyone comparing the two should weigh that gap in evidence before assuming they are interchangeable.

Every vial we list is authentic Syncom Labs product, and each box carries its own verification check-code so you can confirm what you have received. Orders go out from our UK dispatch point on Royal Mail Tracked 24 in plain, unbranded packaging, with most reaching customers within 1 to 2 working days. Get your payment through before midday on a working day and we get it out the same day.